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While the scientific world never underwent a Kuhnian paradigm shift, it still demonstrated its willingness to doing so, had the evidence proved conclusive. And while science does not simply reveal truths waiting to be discovered, but instead engages things and processes that remain indifferent to our assumptions – at least, until we engage them – we should not read Whitehead or Peirce as asserting that only non-rational negotiations with non-human entities yield results . . . Might it be the case that reason has yet to be considered as itself a material or real process, one in which there is no rationality aside from the invocation of potential yet also material or real reasons?